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KMID : 0387420220330030277
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Korean Society of Oriental Neuropsychiatry
2022 Volume.33 No. 3 p.277 ~ p.285
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Protective Effect of Gatrodiae Rhizoma Extracts on the LPS-Induced Cognitive Impairment Model
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Kwon Kang-Beom
Kim Ha-Rim
Kim Ye-Seul
Park Eun-Hee
Kang Hyung-Won
Ryu Do-Gon
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Abstract
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Objectives: Gastrodia elata (GE) has been used to treat cognition impairment, including Alzheimer’s disease (AD) in Korea. The purpose of this study was to investigate the effects of GE water extracts (GEE) on the lipopolysaccharide (LPS)-induced AD model in mice. (Aβ).
Methods: We classified six groups as follow; group 1: control (CON), group 2: LPS (0.5 mg/kg/day, four times), group 3: 4 mg/kg donepezil (DP), group 4: 100 mg/kg GEE+LPS, group 5: 200 mg/kg GEE+LPS, group 6: 500 mg/kg GEE+LPS.
Results: We found that GEE has an effect that inhibits decrease of discrimination index in object recognition test, as well as spontaneous alteration in the Y-maze test by LPS. Treatment with LPS increased amlyloid-β (Aβ) concentration, and decreased brain-derived neurotrophic factor (BDNF) in cerebral cortex of mice. However, GEE significantly protected against LPS-induced Aβ and BDNF changes. Our findings also showed that the inflammatory cytokines 〔tumor necrosis factor-alpha (TNF-α), interleukin- 6 (IL-6) and interleukin-1β (IL-1β)〕 mRNA and protein were up-regulated by the LPS injection. But GEE significantly suppressed LPS-induced inflammatory cytokines increase in a dose-dependent manner.
Conclusions: This study suggests that the GEE may be an effective AD therapeutic agent, in treating neurodegenerative diseases including AD.
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KEYWORD
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Gastrodia elata, Alzheimer’s disease, Lipopolysaccharide, Amlyloid-β, Brain-derived neurotrophic factor, Neurodegenerative diseases
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